Tissue Preservation & Perfusion

AQIX RS-I contains physiological concentrations of all the essential ingredients required to maintain homeostasis at the cell level. It is currently being used to transport, reanimate and perfuse human cadaver tissues and organs for preclinical drug screening.

The same fluid has proved successful for hypothermic storage and transport as well as normothermic perfusion.
It is suitable for a variety of cell, tissue and organ types, across all mammalian species utilized in physiological research and preclinical drug bioassay studies.

It has successfully been utilised in the following animal and human preparations; liver, lung, kidney, heart, vascular tissues, urino-genital tract, gastro-intestinal tract, skeletal and visceral neuromuscular preparations and ES-derived stem cells.
It has also been used as a base solution for carrying human red blood cells and plasma components in ex vivo studies involving human cadaver organs, e.g., heart, lung, liver, kidney, intestine.

Benefits of storing and transporting human cells, tissues and organs in AQIX RS-I are:

1. confidence that tissue samples will arrive in a functionally viable state,
2. confidence that rates of tissue loss will be low,
3. more fresh, viable and ‘hard to preserve’ samples can be recovered,

Benefits of perfusing human or animal tissues or organs in AQIX RS-I are;

1. more accurately replication of clinical responses to drugs,
2. greater precision for potency and safety data,
3. drugs can be trialed repeatedly with consistent responses,
4. confidence that any observed effects are due to the drug rather than that caused by the perfusate solution,
5. preparations survive longer in terms of functional viability,
6. preservation of neuronal activity and organ innervation,
7. enzyme activity is maintained,
8. standardization of physiological, biochemical and pharmacological responses,

These benefits are achieved with a rigorously manufactured, chemically defined, animal product-free and proven, physiological balanced medium.

Overall, potential drug candidates can now be more accurately identified utilizing ex vivo human cells, tissues and organs whereby, their efficacy and clinical safety is more quickly and cost effectively established so as to accelerate drug attrition rates, increase development efficiencies and productivity.

If you would like to try a sample of AQIX RS-I or require further information, please contact us. More information about the variety of applications for this patented, fluid technology can viewed by selecting a link below: